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PD 90780
CAS No. 77422-99-2
PD 90780( —— )
Catalog No. M33057 CAS No. 77422-99-2
PD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 78 | Get Quote |
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| 5MG | 116 | Get Quote |
|
| 10MG | 187 | Get Quote |
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| 25MG | 365 | Get Quote |
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| 50MG | 542 | Get Quote |
|
| 100MG | 759 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePD 90780
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NoteResearch use only, not for human use.
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Brief DescriptionPD 90780 is a non-peptide antagonist of nerve growth factor (NGF) that interacts with NGF and prevents it from binding to p75NTR, inhibiting the NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
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DescriptionPD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
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In VitroPD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR.PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR.PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM.PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number77422-99-2
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Formula Weight362.34
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Molecular FormulaC19H14N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 31.25 mg/mL (86.24 mM; Ultrasonic (<60°C)
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SMILESCn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J ?
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